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MCC 2012 FORUM |
NEUROSCIENCE, REHABILITATION, & POLICY FROM BASIC MOTOR CONTROL TO FUNCTIONAL RECOVERY: INTERNATIONAL HEATH CARE PERSPECTIVES ON NEUROSCIENCE-INFORMED DIAGNOSIS & TREATMENT |
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deadline June th, 2012
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The deadline for the submission of abstracts is
deadline June th, 2012
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An EXAMPLE
REFLEXIVE CONTROL OF GOAL-DIRECTED ARM MOVEMENT BY THE
VISUAL SIGNAL FROM THE TARGET
Sergei Perfiliev, Johan Wessberg.
Institute of
Neuroscience and Physiology, Göteborg University, Göteborg, Sweden
AIMS
Visually
guided arm movement to a target (reaching) is traditionally studied
under the assumption that it is voluntary planned and guided by a motor program
prepared in advance that describes the movement metrics. Support for this
notion was obtained in numerous studies which demonstrated that reaction time
(RT) of reaching is substantially prolonged when parameters of movement are
unknown in advance. It was established that limb selection and specification of
the movement directions are the two most time consuming planning steps, which
require at least 300-450 ms. However, in many previous studies responses were
made by pressing a button or moving a joystick instead of natural reaching to a
target. In contrast, we have recently found that purposeful arm movement
can be produced automatically when an unobstructed response toward a moving target
is allowed, suggesting reflexive control of the arm by the visual signal from
the target. Our aim was to
investigate reaching in paradigms in which reflexive properties of arm movement
would be clearly revealed.
METHODS
Real
objects attached to a string were used as targets. In human experiments a
stationary ball in front of the subjects was abruptly shifted 25-40 cm to the
left or right, with 1.5-3 m/s peak velocity. The subjects were instructed to
concentrate exclusively on the target, keeping both arms equally prepared for
action, and to catch the ball as soon as it started to move with any strategy
that they felt was the most natural. Positions of passive reflexive markers
attached to the ball and to the phalanx of both index fingers were sampled every
2 ms by two optoelectronic tracking cameras (Proreflex,
Qualisys, Sweden). Surface EMG was recorded from
multiple arm and shoulder muscles. In animal experiments, the target suddenly
appeared at a speed of 1 m/s through one of the holes in the sidewalls of a
cage and could be accelerated up to 4 m/s. The animals were unaware from which
side the target will be presented. The animal’s experiments were recorded by
digital video camera.
RESULTS
We
found that cats, monkeys, humans and naïve kittens spontaneously use the same
automated strategy. Targets moving to the right selectively initiated and
directed the right forelimb toward a prospective target position, and vice
versa for targets moving to the left. We refer to this strategy as Interception.
In humans, the earliest onset of EMG activity ranged in different subjects from
90 to 110 ms, which is less than half than was reported before. Intentional
reversal of the Interceptive pattern, i.e. catching the target moving to the
left by the right arm and vice versa (we call this Pursuit), prolonged
RT on average by 60 ms. The surprisingly short RTs of
Interceptive movements indicate that selection of the arm and directing it to
the target were automatically induced by parameters of the target motion and
was not a result of the subject’s voluntary decision. On the basis of these
findings we tentatively suggested hypothesis that arm can be initiated and
guided reflexively by the target.
Our
hypothesis of reflexive arm control was critically tested in a direct arm-tracking
task. Subjects were asked to use their right arm to track directly a ball which
was moved continuously in a vertical plane along a curvilinear, irregular path
with high and variable speed (0.6-1.2 m/s). All subjects could effortlessly
follow the target with very high accuracy (cross-correlation 0.85-0.95) and
short and stable time shift of 90-140 ms between the target’s and subject’s
velocity trajectories. These results suggest control by hardwired circuits
which directly transform with minimal and constant delay the target parameters
into corresponding motor output. Thus, responses with the required parameters
can be generated automatically without advance elaboration of the motor program
and parametric specification of the movement.
In
the final task we tested the effect of an irrelevant distracter (20 mm diameter
white circle) briefly (100 ms) moving across a monitor on the trajectories of
reaching toward a stationary target (40 mm diameter red circle). A switching
paradigm, i.e. on-line trajectory correction when in some trials the
target is unexpectedly shifted left/rightward, was used as a background task to
increase sensitivity of the CNS to moving stimuli. In many trials the
distracter induced a small deviation of the trajectory in the direction of the
distracter motion. This was not noticed by the participants, and was followed
by an immediate correction. The correction was drastically corrupted when we
introduced trials where the main target was switched off at the moment the
distracter appeared. In these trials the arm consistently and involuntarily
followed the distracter, often without any further correction. This strongly
suggests that during reaching to a stationary target, the visual signal from
the target is critical in keeping the arm trajectory on the right track.
CONCLUSIONS
In
summary, the present data indicates that direct and unobstructed
reaching toward moving and stationary targets is continuously guided in a reflexive
fashion by the visual signal from the target. This suggests that in the
previous paradigms that were commonly used to assess motor programming, generation of the
movement was delayed due to spatial incompatibility between the target and the
response. This resulted in construction of misleading notions of voluntary
control and parametric programming of arm movement in space.